You need to call 0800 091 1629 and speak to a cruise specialist there are lots leaving the UK - 17 Aug 08 for 14 nights. 9 ports in 8 countries
Southampton, Vigo, Lisbon, Palma, Barcelona, Cannes, Rome, Ajaccio, Gibraltar, Southampton and this does not involve flying but there are many many more.
There are lots of cruises sailing to and from the UK ranging in duration from 2 days to several weeks and lots for two weeks. These cover Norway, Baltic, Med, Canaries. For three weeks you can go to the Caribbean, North America. If you want longer you can go round the world. Cruise lines include P&O, Cunard, Royal Caribbean, Princess, Fred Olsen, Saga, NCL.
...and Carnival, and Celebrity, and SilverSeas, and Costa, and Voyages of Discovery. It would probably be shorter to list the cruise lines that don't sail from the UK!
Yes you can. P & O depart from Southampton sometimes Thomson and Portland go from Harwich just key in on the search engine find me cruises that go from the UK and you ill find some.
Also check out Thomson's cruises FROM UK, I'm leaving from Harwich next week, heading for Scandinavia - the Baltic region. No flying involved.